Thermo Fisher Scientific Erythropoietin (EPO) Recombinant Mouse Monoclonal Antibody (rEPO, 1367)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 2–4 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris Buffer with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors.
EPO induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins such as hemoglobin.
The EPO receptor (EPOR) is highly expressed on precursor cells and decreases with cell maturation.
Hepatocytes are the main source of EPO in the fetus, while interstitial kidney cells are the primary source after birth and in adulthood.
EPO expression is upregulated during hypoxia, with low transcription levels also detected in lung and brain tissue.
Recent studies suggest EPO may contribute to neuronal tissue protection and repair initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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