Thermo Fisher Scientific Phospho-c-Met (Tyr1003) Monoclonal Antibody (J.119.10)
Phospho-c-Met (Tyr1003) 단일클론 항체로 인간, 마우스, 랫트에 반응하며 Western blot에 적합합니다. 비접합 액상 형태로 친화 크로마토그래피 정제. 세포 신호전달 및 암 관련 연구용으로 사용됩니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.119.10 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1003 of human Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11009494 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions lead to activation of signaling cascades including RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC.
MET plays a role in embryonic development including gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers such as gastric, renal, and breast, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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