Thermo Fisher Scientific IDH1 Monoclonal Antibody (G132.1)
IDH1 단백질의 R132H 변이를 인식하는 마우스 모노클로날 항체로, 인간 시료에 반응합니다. 파라핀 조직 IHC에 적합하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용되며 2–8°C에서 보관합니다.
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Thermo Fisher Scientific IDH1 Monoclonal Antibody (G132.1)
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G132.1 |
| Immunogen | Synthetic peptide corresponding to the region of human IDH1 that includes a point mutation at residue 132 where Arginine (R) is changed to Histidine (H) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | Tris, pH 7.3–7.7, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 2–8°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors. Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent forms located in the mitochondrial matrix and two NADP(+)-dependent forms, one mitochondrial and one predominantly cytosolic. The NADP(+)-dependent isozyme is a homodimer found in cytoplasm and peroxisomes, containing a PTS-1 peroxisomal targeting signal sequence. This enzyme contributes to NADPH regeneration for peroxisomal reductions and cytoplasmic NADPH production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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