Thermo Fisher Scientific TIM3 Monoclonal Antibody (G003.1)
인간 TIM3 단백질을 인식하는 Mouse IgG1 단클론 항체로, IHC(파라핀) 분석에 적합합니다. 단백질 A로 정제된 액상 형태이며, -20°C에서 보관합니다. 면역 연구 및 자가면역 질환 관련 기초 연구용으로 활용됩니다.
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Thermo Fisher Scientific TIM3 Monoclonal Antibody (G003.1)
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:100–1:200
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G003.1 |
| Immunogen | Recombinant human TIM-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | Tris, pH 7.3–7.7, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases, down-regulates Th1-mediated immune responses, and facilitates immune tolerance.
Pathological significance includes association with experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, enhancing its severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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