Thermo Fisher Scientific Heart Fatty Acid Binding Protein (H-FABP)/FABP3 Monoclonal Antibody (FABP3/3430)

Applications

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human heart or skeletal muscle
• Cellular Localization: Cytoplasm

Specificity Comments

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family divided into hepatic-, intestinal-, and cardiac-type. They form 14–15 kDa proteins and are involved in uptake, intracellular metabolism, and transport of long-chain fatty acids. FABP3 gene contains four exons and functions to arrest growth of mammary epithelial cells, acting as a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants.

Target Information

Fatty acid binding proteins (FABPs) are small (approximately 13–14 kDa) intracellular proteins with high tissue specificity. They bind long-chain fatty acids and are abundant in various cell types, playing a key role in intracellular fatty acid utilization. There are at least six distinct types of FABP, each with specific tissue expression patterns. Due to their small size, FABPs leak rapidly from damaged cells, leading to increased serum levels. Liver FABP serves as a sensitive marker for liver cell damage and hepatocyte lysis, useful in toxicology assays and transplantation monitoring.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.