Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
c-Myc 단백질의 Ser62 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합. 인간, 생쥐, 랫드 반응성. 액상 형태로 1 mg/mL 농도, PBS buffer 및 50% glycerol 함유. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MYC (Accession P01106), corresponding to amino acid residues around phosphorylated Ser62. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816202 |
Product Specific Information
This antibody detects endogenous levels of c-Myc only when phosphorylated at Serine 62.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is functionally linked to cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis and contributes to oncogenesis in multiple tissues.
Amplification or translocation of the c-Myc gene is associated with numerous cancers, including lung, breast, colon carcinomas, and Burkitt’s lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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