Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Tyr537) Polyclonal Antibody
인간, 마우스, 랫트 시료에서 Tyr537 인산화된 Estrogen Receptor alpha를 특이적으로 검출하는 rabbit polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며, 1mg/mL 농도의 액상 형태로 제공. PBS/glycerol buffer에 보관하며 -20°C에서 안정.
- 카탈로그번호
- PA5104732
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESR1 (Accession P03372), corresponding to amino acid residues around phosphorylated Tyr537. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816205 |
Product Specific Information
This antibody detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at Tyrosine 537.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. ER can regulate gene transcription positively or negatively through coactivator or corepressor recruitment.
Two forms of the estrogen receptor exist—alpha and beta—encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four known ERα isoforms (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are broadly expressed and play essential roles in sexual development, reproductive function, and bone physiology. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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