Thermo Fisher Scientific Phospho-c-Myc (Thr58) Polyclonal Antibody
c-Myc 단백질의 Thr58 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody입니다. Western blot, IHC, ICC, IP 등 다양한 응용에 사용 가능합니다. 인간, 마우스, 랫트 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MYC (Accession P01106), corresponding to amino acid residues around phosphorylated Thr58 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816203 |
Product Specific Information
This antibody detects endogenous levels of c-Myc only when phosphorylated at Threonine 58.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to regulation of cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Dysregulated expression of c-Myc can induce apoptosis and is implicated in multiple cancers, including lung, breast, colon, and Burkitt’s lymphoma.
Antibodies against c-Myc epitopes also recognize proteins fused with Myc tags at either terminus. Amplification or translocation of the c-Myc gene is commonly observed in various human tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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