Thermo Fisher Scientific TNFR1 Monoclonal Antibody (H398), Biotin
인간 TNFR1에 특이적인 Mouse IgG2a 단클론 항체로 Biotin 결합형. Western blot, Flow cytometry, Immunoprecipitation 등 다양한 어플리케이션에 사용 가능. Protein G 정제, PBS/BSA buffer 저장, 4°C 보관.
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Thermo Fisher Scientific TNFR1 Monoclonal Antibody (H398), Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay (Functional) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H398 |
| Immunogen | Affinity-purified receptor material from HL60 cells containing ~9 µg actively binding receptor |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3093171 |
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. It plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 can be released as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signal transduction. Germline mutations in TNFR1 are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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