Thermo Fisher Scientific MEKK4 Polyclonal Antibody
MEKK4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. 인간과 생쥐 시료에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K4 (Accession Q9Y6R4), corresponding to amino acid residues A60–R110. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818257 |
Product Specific Information
Antibody detects endogenous levels of total MAP3K4.
Target Information
This gene encodes a TBP (TATA box-binding protein)-associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo, and this phosphorylation affects its interaction with TBP. It contains a histone fold motif at the N-terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which altered DNA conformation and higher-order complex formation inhibit preinitiation complex assembly and regulate RNA polymerase II transcription rate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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