Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (L243)
HLA-DRB (MHC II) 단백질을 인식하는 L243 클론의 단일클론 항체로, 인간 및 다양한 종에 반응합니다. ICC/IF 및 유세포분석(Flow Cytometry)에 적합하며, 비결합형 액상 형태로 제공됩니다. 면역학 및 항원제시 연구에 활용 가능합니다.
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Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (L243)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg / 10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Chimpanzee, Human, Non-human primate, Rodent |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | L243 |
| Immunogen | Activated human peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, a member of the human leukocyte antigen (HLA) class II molecule family. The HLA-DR beta chain is encoded by the HLA-DRB gene and is primarily expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.
These cells are essential for immune system function, capturing and presenting antigens to T cells for immune recognition. HLA-DR beta plays a critical role in presenting antigenic peptides to CD4⁺ T cells, activating adaptive immune responses.
Structurally, HLA-DR beta includes:
- Extracellular domain: Contains the peptide-binding groove interacting with antigenic peptides
- Transmembrane domain: Anchors the chain to the cell membrane
- Cytoplasmic tail: Involved in intracellular signaling
HLA and MHC antibodies are key tools in Immunopeptidomics, supporting neoantigen identification and characterization via high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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