Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (L243)

Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (L243)

Applications and Tested Dilution

Product Specifications

Target Information

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, a member of the human leukocyte antigen (HLA) class II molecule family. The HLA-DR beta chain is encoded by the HLA-DRB gene and is primarily expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.

These cells are essential for immune system function, capturing and presenting antigens to T cells for immune recognition. HLA-DR beta plays a critical role in presenting antigenic peptides to CD4⁺ T cells, activating adaptive immune responses.

Structurally, HLA-DR beta includes:

• Extracellular domain: Contains the peptide-binding groove interacting with antigenic peptides
• Transmembrane domain: Anchors the chain to the cell membrane
• Cytoplasmic tail: Involved in intracellular signaling

HLA and MHC antibodies are key tools in Immunopeptidomics, supporting neoantigen identification and characterization via high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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