Thermo Fisher Scientific CD27 Monoclonal Antibody (OTI2D11)

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily, which includes CD40 and CD30. This family regulates cell proliferation and death.
CD27 and its ligand CD70 are mainly expressed in lymphocytes. High CD27 expression depends on antigen receptor ligation, while CD70 requires co-stimulatory or pro-inflammatory signals.
CD27 forms disulfide-linked homodimers on mature thymocytes, peripheral blood T cells, and some B cells. Activation of T cells increases CD27 expression and releases soluble CD27 (sCD27), detected in plasma, urine, or spinal fluid.
Soluble CD27 serves as a prognostic marker for B cell malignancies. CD27-binding protein (SIVA) is a proapoptotic molecule involved in CD27-mediated apoptosis.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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