Thermo Fisher Scientific MCK10 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MCK10 (DDR1) protein. Validated for IHC (paraffin) with recommended dilution 15–20 µg/mL. High species homology and affinity-purified. Suitable for research on cell adhesion, migration, and receptor tyrosine...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested dilution: 15–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminus of human DDR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550182 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- 100%: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Opossum
- 95%: Mouse, Rat, Dog, Bovine, Hamster, Panda, Horse, Rabbit, Pig
- 90%: Xenopus
- 85%: Pufferfish, Stickleback
- 80%: Zebrafish
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
DDR1 (MCK10) is a receptor tyrosine kinase activated by collagen and regulates adhesion, cell migration, and other cellular processes.
Receptor tyrosine kinases (RTKs) are key in cell communication with the microenvironment and regulate growth, differentiation, and metabolism.
DDR1 is widely expressed in epithelial cells and activated by various collagen types (I–VI). Expression is particularly high in kidney, lung, gastrointestinal tract, and brain, and overexpressed in several human tumors (breast, ovarian, esophageal, pediatric brain).
The DDR1 gene is located on chromosome 6p21.3 near HLA class I genes, and alternative splicing produces multiple variants.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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