Thermo Fisher Scientific MMP2 Monoclonal Antibody (2C1-1D12)
MMP2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ELISA 등 다양한 응용에 적합. Human 시료에 검증됨. 비결합형 액상 형태로 제공되며, -20°C에서 보관. 조직 재형성과 관련된 MMP2 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10 - 1:100 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL | - |
| ELISA | 0.1 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1-1D12 |
| Immunogen | Activated recombinant human MMP-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533195 |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved amino acid sequence in the metal-binding active site and are regulated by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play critical roles in angiogenesis regulation.
MMP2 is synthesized as a 631-amino acid proenzyme, activated by cleavage of the first 80 amino acids, and consists of propeptide, catalytic, and hemopexin domains. MMP2 participates in tissue remodeling and can degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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