Thermo Fisher Scientific MMP2 Monoclonal Antibody (2C1-1D12)

Applications and Tested Dilutions

Product Specifications

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved amino acid sequence in the metal-binding active site and are regulated by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play critical roles in angiogenesis regulation.

MMP2 is synthesized as a 631-amino acid proenzyme, activated by cleavage of the first 80 amino acids, and consists of propeptide, catalytic, and hemopexin domains. MMP2 participates in tissue remodeling and can degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.