Thermo Fisher Scientific SMURF1 Polyclonal Antibody
SMURF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 분석에 적합하며, 인간과 생쥐에서 반응. 액상 형태로 제공되며 0.5 mg/mL 농도, PBS 버퍼에 sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PA511943
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 66–96 amino acids from the N-terminal region of human SMURF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2193832 |
Product Specific Information
This antibody is predicted to react with Xenopus and zebrafish based on sequence homology.
Target Information
Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which activate the SMAD signaling pathway.
Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas activin and TGFB receptors (e.g., ACVR1 and TGFBR1) target SMAD2 and SMAD3.
Phosphorylation of these SMADs induces association with SMAD4.
Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity, maintaining tumor cell morphology and motility.
PKC-zeta, part of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to protrusions to control RhoA levels, linking polarity to RhoA degradation during membrane dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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