Thermo Fisher Scientific NEFM Monoclonal Antibody (OTI2G3), TrueMAB
인간 NEFM 단백질(aa 413-773)을 항원으로 제작된 마우스 단클론 항체로, 신경세포 내 중간 필라멘트 단백질 검출에 적합합니다. Western blot과 IHC(Paraffin)에서 높은 특이성과 재현성을 제공하며, 액상 형태로 -20°C에서 안정적으로 보관됩니다.
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- TA805823
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 413–773 of human NEFM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neurofilaments (NFs) are intermediate filaments expressed almost exclusively in neuronal cells, particularly in large axons. They consist of three polypeptide chains—NF-M, NF-H, and NF-L—that share a coiled-coil core domain but differ in terminal regions. The NF-M tail domain mediates interactions critical for axonal size and cytoskeletal architecture. NF-M phosphorylation and O-GlcNAcylation are reciprocally regulated, influencing filament formation and function. Antibodies to neurofilament subunits serve as reliable neuronal markers due to their abundance, neuron-specific expression, and biochemical stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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