Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI2F5), TrueMAB
GEMIN8 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot에 적합. 인간 시료 반응성, 1 mg/mL 농도의 액상 제품. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is crucial for splicing of cellular pre-mRNAs.
Most spliceosomal snRNPs contain Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA to create the core snRNP.
In the cytosol, Sm proteins (SNRPD1, SNRPD2, SNRPE, SNRPF, SNRPG) are initially trapped in an inactive 6S pICln-Sm complex by chaperone CLNS1A. The SMN complex dissociates CLNS1A and transfers Sm proteins to the SMN-Sm complex, initiating assembly and nuclear transport of snRNPs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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