Thermo Fisher Scientific PTP1B Monoclonal Antibody (3A7)
PTP1B 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3A7). Western blot과 ICC/IF에 적합하며 HepG2 세포를 양성 대조군으로 권장. 비결합형 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A7 |
| Immunogen | Purified, recombinant, human PTP1B protein expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1086930 |
Product Specific Information
A suggested positive control for this product is HepG2 cells.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase that acts as a regulator of the endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, thereby inactivating its kinase activity. PTP1B also participates in CKII- and p60c-src-induced signal transduction cascades and regulates the EFNA5-EPHA3 signaling pathway, which modulates cell reorganization and cell-cell repulsion. Additionally, PTP1B controls the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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