Thermo Fisher Scientific PDE4B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, H1299, U87-MG, SK-N-SH, rat brain
• Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (89%), Pig (98%), Chicken (93%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals such as hormones, light, and neurotransmitters.
The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction.
This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.