Thermo Fisher Scientific Phospho-Alpha-synuclein (Tyr136) Polyclonal Antibody
인간, 마우스, 랫트 시료에서 인산화된 Alpha-synuclein(Tyr136)을 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 파킨슨병 및 알츠하이머병 연구용으로 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SNCA (Accession P37840), corresponding to amino acid residues around phosphorylated Tyr136 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818305 |
Product Specific Information
This antibody detects endogenous levels of alpha-synuclein only when phosphorylated at Tyrosine 136.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to the pathogenesis of Parkinson’s disease. Alpha-synuclein peptides are also major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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