Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser118) Polyclonal Antibody
Phospho-Estrogen Receptor alpha (Ser118)를 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인산화된 Ser118 잔기에서만 내인성 ERα를 검출합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESR1 (Accession P03372), corresponding to amino acid residues around phosphorylated Ser118 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818280 |
Product Specific Information
This antibody detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at Serine 118.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. Through this mechanism, ER can regulate gene transcription by recruiting coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four isoforms of estrogen receptor-alpha are known (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are expressed in various tissues and are essential for sexual development, reproductive function, and bone maintenance. They are also implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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