Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser167) Polyclonal Antibody
인간 ESR1 유래 인산화 Ser167 부위 특이적 인식 항체로, Western blot, IHC, ICC/IF에 사용 가능. 내인성 Estrogen Receptor alpha의 인산화 상태 검출에 적합. -20°C 보관, 1 mg/mL 농도의 액상 형태.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESR1 (Accession P03372), corresponding to amino acid residues around phosphorylated Ser167 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818278 |
Product Specific Information
This antibody detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at Serine 167.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon estrogen binding, undergoes conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. ER regulates gene transcription positively or negatively through coactivator or corepressor recruitment.
Two distinct forms exist—ER alpha and ER beta—encoded by ESR1 and ESR2 genes. Alternative RNA splicing produces at least four ER-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed across tissues, playing crucial roles in sexual development, reproduction, bone metabolism, and pathological processes such as breast and endometrial cancers, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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