Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI3E7)
RFXANK 단백질을 인식하는 마우스 모노클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. 인간 시료 반응성이 있으며, 비결합형 액상 형태로 제공됩니다. 면역학 연구 및 MHC class II 관련 유전자 발현 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E7 |
| Immunogen | Full length human recombinant protein of RFXANK produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725222 |
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in immune system development and regulation. The RFXANK protein, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of MHC class II gene promoters and activates transcription. This complex associates with the MHC class II transactivator, controlling cell type specificity and inducibility of gene expression. RFXANK contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene are linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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