Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI3C10)

Applications and Tested Dilution

Product Specifications

Target Information

Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in immune system development and regulation. The protein encoded by the RFXANK gene, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. This complex associates with the non-DNA-binding factor MHC class II transactivator, which determines cell type specificity and inducibility of MHC class II gene expression. The protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one isoform showing activation activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.