Thermo Fisher Scientific NK1.1 Chimeric Recombinant Mouse Monoclonal Antibody (PK-136)
마우스 NK1.1 항원을 인식하는 재조합 단클론 항체로, Flow Cytometry 및 Functional Assay에 적합합니다. HEK293 세포에서 발현된 IgG2a 아이소타입 항체이며, Protein A로 정제되었습니다. NK 세포 활성 및 면역반응 연구용으로 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PK-136 |
| Immunogen | The original antibody was generated by immunizing (C3H X BALB)F1 mice with spleen cells enriched for NK-1 cells and bone marrow cells from CE mice. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody reacts with murine NK1.1, a type II integral membrane glycoprotein containing a C-type lectin domain. NK1.1 plays a stimulatory role in NK cell cytotoxicity. Activation through receptor cross-linking induces Ca²⁺ mobilization and interferon-gamma production.
Target Information
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1; KLRB1; NKR-P1A; CD161) is expressed on Natural Killer (NK) cells and certain T cell subsets. It mediates cytotoxicity and cytokine secretion upon immune stimulation. The KLRB1 protein is a type II membrane protein with extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain. NKR-P1A recognizes Lectin Like Transcript-1 (LLT1) as its functional ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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