Thermo Fisher Scientific SETD7 Monoclonal Antibody (OTI2D10), TrueMAB
SETD7 단백질을 인식하는 단클론 항체로, 인간·마우스·개·쥐 시료에 반응. WB, IHC, ICC, Flow 등 다양한 응용 가능. 고순도 액상 항체로 안정적인 결과 제공. 연구용으로만 사용.
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Thermo Fisher Scientific SETD7 Monoclonal Antibody (OTI2D10), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D10 |
| Immunogen | Full length human recombinant protein of human SETD7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in the transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, leading to transcription activation.
Has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7.
Monomethylates Lys-189 of TAF10, increasing affinity for RNA polymerase II.
Monomethylates Lys-372 of p53/TP53, stabilizing and enhancing transcriptional activation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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