Thermo Fisher Scientific Alpha-2-Macroglobulin Monoclonal Antibody (A2M, 3621)
Thermo Fisher Scientific의 Alpha-2-Macroglobulin Monoclonal Antibody (A2M, 3621)는 인간 시료에 반응하는 Mouse IgG2c 항체로, IHC 및 Peptide Array에 사용 가능. 고순도 Protein A/G 정제, 무보존액 PBS 용액 형태로 제공. Alzheimer’s 연구 등 단백질 결합 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2M, 3621 |
| Immunogen | Human recombinant A2M protein fragment (around aa 604–748) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
Alpha-2-Macroglobulin (A2M) is an approximately 720 kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits.
A2M shares structural similarities with other alpha-macroglobulins such as complement components C3 and C4 and pregnancy zone protein (PZP), and exhibits a broad ligand-binding capacity.
It functions as a humoral defense barrier against foreign peptides by capturing various proteinases, acting as a panprotease inhibitor.
In Alzheimer’s disease (AD) brains, A2M is localized in diffuse amyloid plaques, suggesting a role in AD pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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