Thermo Fisher Scientific Phospho-PDGFRB (Tyr771) Polyclonal Antibody
PDGFRB (Tyr771) 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot에 최적화되어 있으며 인간 및 생쥐 시료에 반응. 항원 친화 크로마토그래피로 정제되었으며 안정적인 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
Species Reactivity
Human, Mouse
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human PDGF Receptor beta (phospho Tyr771). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792935 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Bovine (100%).
- Positive Control: PDGF-treated NIH-3T3.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is located on chromosome 5, near the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with ETV6 results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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