Thermo Fisher Scientific CD56 Monoclonal Antibody (RNL-1)
인간 및 마우스 시료에서 NCAM(CD56)을 검출하는 단클론 항체로, IHC(F) 및 ICC/IF에 적합합니다. 소세포폐암 세포주 NCI-H82 유래 면역원으로 제작되었으며, 1 mg/mL 농도의 액상 형태입니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- MA106800
- 판매단위
- pk
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 1:100–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RNL-1 |
| Immunogen | Small cell lung cancer cell line NCI-H82 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558239 |
Product Specific Information
MA1-06800 detects NCAM in human and mouse samples.
MA1-06800 has been successfully used in immunohistochemistry and immunocytochemistry procedures.
The MA1-06800 immunogen is a membrane preparation of the small cell lung cancer cell line NCI-H82.
Store at 4ºC or in small aliquots at -20ºC.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
Further, CD56 is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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