Thermo Fisher Scientific CD56 Monoclonal Antibody (RNL-1)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:100–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:200

Product Specifications

Product Specific Information

MA1-06800 detects NCAM in human and mouse samples.
MA1-06800 has been successfully used in immunohistochemistry and immunocytochemistry procedures.
The MA1-06800 immunogen is a membrane preparation of the small cell lung cancer cell line NCI-H82.
Store at 4ºC or in small aliquots at -20ºC.

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
Further, CD56 is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.