Thermo Fisher Scientific CD357 (AITR/GITR) Chimeric Recombinant Rabbit Monoclonal Antibody (YGITR765)
마우스 GITR 단백질에 특이적으로 결합하는 재조합 토끼 단클론 항체. ICC/IF, Flow Cytometry, Inhibition Assay에 사용 가능. HEK293 세포 발현, Protein A 정제, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1 µg/mL |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | YGITR765 |
| Immunogen | nB2/6TG cells transfected with mouse GITR injected into DA rats |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074464 |
Product Specific Information
This antibody specifically binds murine GITR.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene located on chromosome 1p36.33. This receptor, part of the TNF-receptor superfamily, shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice suggest its involvement in regulating CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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