Thermo Fisher Scientific Somatostatin Monoclonal Antibody (ICDCLS), Biotin, eBioscience

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

0.5 µg/mL

-

Product Specifications

Published species

Mouse

Host/Isotype

Mouse / IgG1, kappa

Recommended Isotype Control

Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

ICDCLS

Conjugate

Biotin Biotin Biotin

View additional formats

• Unconjugated
• eFluor 660
• Request custom conjugation

Form

Liquid

Concentration

0.5 mg/mL

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2572822

Product Specific Information

Description: The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin. Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or somatotrophin release-inhibiting factor (SRIF), is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein. Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas as well as by the hypothalamus and intestine. Somatostatin has a variety of functions, such as regulating the endocrine system and affecting neurotransmission and cell proliferation. Somatostatin also inhibits the release of numerous secondary hormones, such as insulin and glucagon. Somatostatin can be used to identify medium size aspiny neurons in the striatum, cortex, and hippocampus. Expression of somatostatin is present in hyperplasia of the pancreatic islets as well as islet cell tumors such as somatostatinomas.

Applications Reported: This ICDCLS antibody has been reported for use in immunohistochemical staining, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.

Applications Tested: This ICDCLS antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using low pH antigen retrieval and can be used at less than or equal to 0.5 µg/mL. It is recommended that the antibody be carefully titrated for opitmal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.