Thermo Fisher Scientific Somatostatin Monoclonal Antibody (ICDCLS), Biotin, eBioscience

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• eFluor 660
• Request custom conjugation

Product Specific Information

The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin.
Somatostatin (growth hormone-inhibiting hormone, GHIH; somatotrophin release-inhibiting factor, SRIF) is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein.

Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas, as well as by the hypothalamus and intestine. It regulates the endocrine system, affects neurotransmission and cell proliferation, and inhibits the release of secondary hormones such as insulin and glucagon.

Somatostatin can be used to identify medium-size aspiny neurons in the striatum, cortex, and hippocampus. Expression is present in hyperplasia of pancreatic islets and in islet cell tumors such as somatostatinomas.

Applications Reported:
This ICDCLS antibody has been reported for use in immunohistochemical staining and in immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.

Applications Tested:
This antibody has been tested by immunohistochemistry of formalin-fixed paraffin-embedded tissue using low pH antigen retrieval and can be used at ≤ 0.5 µg/mL.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Target Information

The hormone Somatostatin has active 14 aa and 28 aa forms produced by alternate cleavage of a single preproprotein.
It is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors.

Somatostatin plays a key role in regulating the endocrine system through interactions with pituitary growth hormone, thyroid stimulating hormone, and gastrointestinal hormones.
It also influences neurotransmission in the CNS and proliferation of both normal and tumorigenic cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.