Thermo Fisher Scientific Phospho-LRP5 (Tyr1473) Polyclonal Antibody
LRP5 단백질의 Tyr1473 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 검증 완료. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태, PBS/glycerol buffer에 보관. 연구용 전용.
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- PA5105096
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LRP5 (Accession O75197), corresponding to amino acid residues around phosphorylated Tyr1473 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816569 |
Product Specific Information
This antibody detects endogenous levels of LRP5 only when phosphorylated at Tyr1473.
Target Information
LDL-related proteins LRP5 and LRP6 are members of the LDL receptor superfamily involved in the canonical Wnt signaling pathway.
Mammalian LRP6 binds Wnt1 and enhances Wnt-induced developmental processes in Xenopus embryos.
Mice lacking LRP6 exhibit developmental defects similar to those caused by deficiencies in various Wnt proteins.
Wnt proteins induce the binding of LRP5 to Axin, leading to Axin degradation and β-catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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