Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI3C3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells.
It is encoded by the IL1A gene on chromosome 2q13 and signals through receptors IL-1RI and IL-1RII, shared with IL-1 beta.
IL-1 alpha plays a crucial role in innate immunity by inducing other proinflammatory cytokines and acute-phase responses.
Its activity is modulated by IL-1 Receptor Antagonist (IL-1RA), which competitively inhibits receptor binding.
IL-1 alpha also regulates NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 (PTGS2) expression, and enhances NO production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.