Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI2F11), TrueMAB
인간 IL1A에 특이적인 마우스 단클론 항체로, WB, IHC(P), ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, 무보존제 제형. IL-1α 연구용으로 염증 및 면역 반응 연구에 적합.
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Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI2F11), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F11 |
| Immunogen | Full length human recombinant protein of human IL1A produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene located on chromosome 2q13 and signals through IL-1RI and IL-1RII receptors, shared with IL-1 beta.
IL-1 alpha is crucial in innate immunity, promoting production of other proinflammatory cytokines and initiating acute-phase responses. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which competitively inhibits receptor binding.
IL-1 alpha influences NF-kappaB and MAP kinase pathways, stimulates IL6 and COX-2 expression, and enhances nitric oxide production. Elevated IL-1 alpha levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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