Thermo Fisher Scientific Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3)
Recombinant rabbit monoclonal antibody recognizing phospho-Lck (Tyr505). Validated for WB and Flow Cytometry. Offers high specificity, lot-to-lot consistency, and animal-origin-free formulation. Suitable for studying T-cell signaling pathways.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | LckY505-A3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr505 of human phospho Lck. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745025 |
Available Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
LCK is a member of the Src-family tyrosine kinases essential for T-cell receptor (TCR) signaling. Upon TCR activation, LCK phosphorylates ITAM motifs in the zeta subunits, creating binding sites for the SH2 domains of ZAP70. Activated ZAP70 phosphorylates adaptor LAT, forming signaling platforms for downstream pathways.
Most LCK localizes to the plasma membrane, with a fraction associated with the Golgi apparatus, potentially contributing to Raf activation during weak TCR stimulation. LCK contains N-terminal myristylation and palmitylation sites, a PTK domain, and SH2/SH3 domains that mediate protein-protein interactions. It also regulates apoptosis induced by various stimuli, excluding death receptor-mediated pathways.
Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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