Thermo Fisher Scientific Phospho-SLP76 (Tyr128) Recombinant Rabbit Monoclonal Antibody (SLP76Y128-3F8)
Human 및 Mouse 시료에서 Tyr128 위치의 인산화 SLP-76 단백질을 검출하는 재조합 Rabbit Monoclonal 항체. 높은 특이성과 감도를 제공하며, Flow Cytometry에 최적화. Lot-to-lot 일관성 및 동물 유래 성분 무첨가 포뮬레이션.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SLP76Y128-3F8 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745026 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal production candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
SLP-76 is a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in Jurkat T cells. The human SLP-76 gene is localized to chromosome 5q33 and encodes a 533 amino acid protein sharing 72% identity with the murine counterpart.
This adaptor protein contains:
- NH2-terminus: Acidic region with PEST domain and phosphorylated tyrosine residues
- Central region: Proline-rich domain
- COOH-terminus: SH2 domain
SLP-76 interacts with multiple proteins constitutively and inducibly after receptor activation, functioning as a scaffold protein. Studies using SLP-76 deficient cells or mice demonstrate its role in T cell development, activation, mast cell, and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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