Thermo Fisher Scientific CD127 Polyclonal Antibody, PE

Applications

Flow Cytometry (Flow)

• 사용 희석: 10 µL per million cells

Product Specifications

Product Specific Information

In direct ELISAs, approximately 60% cross-reactivity with recombinant mouse IL-7 R alpha and less than 10% cross-reactivity with recombinant human IL-7 R alpha is observed.

Target Information

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 depends on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, primarily activates signal transduction by the IL7R complex, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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