Thermo Fisher Scientific alpha-1a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (JE62-50)
alpha-1a 아드레날린 수용체를 인식하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ICC, Flow Cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태로 공급됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE62-50 |
| Immunogen | Synthetic peptide within human alpha 1a Adrenergic Receptor aa 200–250/466 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931281 |
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor (GPCR) superfamily that bind the endogenous catecholamines epinephrine and norepinephrine.
There are nine known receptor subtypes:
- Alpha-1 AR subtypes: 1A/D, 1B, 1C
- Alpha-2 AR subtypes: 2A, 2B, 2C
- Beta AR subtypes: 1, 2, 3
These receptors play key roles in various physiological and pathological processes such as:
- Hypertension and cardiac dysfunction (heart failure, ischemia, arrhythmias)
- Diabetes and glaucoma
- Depression and impotence
Alpha-1A adrenergic receptor (A1AR) subtypes are involved in regulating blood pressure through vascular tone and cardiac output modulation. They also affect uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70) expression, proto-oncogene expression, and mitogenesis.
Additionally, norepinephrine activation of alpha-1 AR can increase nitric oxide synthase (NOS) levels in the hypothalamus, which may influence hormone release such as LH, androgens, estrogen, and progesterone.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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