Thermo Fisher Scientific ABRA1 Recombinant Rabbit Monoclonal Antibody (JE62-73)
인간 CCDC98(Abraxas 1) 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. HEK293 발현 시스템을 사용하며 Protein A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE62-73 |
| Immunogen | Synthetic peptide within human CCDC98 aa 360–409/409 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931283 |
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Depletion of either CCDC98 or RAP80 increases sensitivity to ionizing radiation, suggesting their partial role in BRCA1-mediated DNA damage response. At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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