Thermo Fisher Scientific CLEC12A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLEC12A,uniProtId:Q5QGZ9-2,ncbiNodeId:9606,antigenRange:66-265,antigenLength:265,antigenImageFileName:PA5-120980_CLEC12A_Q5QGZ9-2_Rabbit.svg,antigenImageFileNamePDP:PA5-120980_CLEC12A_Q5QGZ9-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.72 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914552

Product Specific Information

Positive test controls include: K-562. The target is usually found in the following locations: Cell membrane, Single-pass type II membrane protein.

Immunogen sequence: VTLKIEMKKM NKLQNISEEL QRNISLQLMS NMNISNKIRN LSTTLQTIAT KLCRELYSKE QEHKCKPCPR RWIWHKDSCY FLSDDVQTWQ ESKMACAAQN ASLLKINNKN ALEFIKSQSR SYDYWLGLSP EEDSTRGMRV DNIINSSAWV IRNAPDLNNM YCGYINRLYV QYYHCTYKKR MICEKMANPV QLGSTYFREA

Target Information

CD371 is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.