Thermo Fisher Scientific Phospho-Bombesin Receptor 2 (Thr359, Ser360) Polyclonal Antibody
Human GRPR 인산화 Thr359/Ser360 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human BB2 around the phosphorylation site of Thr359/Ser360 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. GRP acts as a potent mitogen for neoplastic tissues.
The effects of GRP are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway.
GRPR is aberrantly expressed in various cancers such as lung, colon, and prostate.
An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the GRPR gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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