Thermo Fisher Scientific PCP4 Polyclonal Antibody
PCP4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간 및 설치류 등 다양한 종 반응성. 액상 형태로 -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PA5103665
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PCP4 (Accession P48539), corresponding to amino acid residues M1–A42 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852999 |
Product Specific Information
Antibody detects endogenous levels of total PCP4.
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates calcium-dependent binding properties of CaM and regulates the rates of calcium association and dissociation from the C-terminal domain of CaM. The IQ motif contains a serine residue phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas and neurodegenerative disorders such as Alzheimer’s and Huntington’s disease. Overexpression of PCP-4 may contribute to cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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