Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 표적하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 인간 IRAK C-말단 펩타이드를 면역원으로 사용. 비결합형 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 2–4 µg |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide: C-terminus of human IRAK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1958259 |
Product Specific Information
- Recommended positive controls: THP-1 or HeLa whole cell lysate
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Additionally, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and degradation, and also phosphorylates IRF7 to induce its activation and nuclear translocation. This process results in transcriptional activation of type I IFN genes, driving the cell into an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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