ELK Biotechnology AMPKβ1 (phospho Ser182) rabbit pAb
AMPKβ1 (phospho Ser182) rabbit polyclonal antibody로, AMPK 에너지 센싱 효소의 인산화 상태를 검출. WB, IHC, IF, ELISA에 사용 가능. 고순도 IgG, 1 mg/ml 농도. 인간, 마우스, 랫, 원숭이에 반응.
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제품명
AMPKβ1 (phospho Ser182) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AMPK beta1 around phosphorylation site of Ser181 (AA range: 147–196) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kD |
| Gene ID (Human) | 5564 |
| Human Swiss-Prot No. | Q9Y478 |
| Cellular Localization | Nucleus, nucleoplasm, cytosol, nucleotide-activated protein kinase complex |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. It acts as an energy-sensing enzyme that monitors cellular energy status. Upon metabolic stress, AMPK becomes activated and phosphorylates key enzymes such as acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), which regulate fatty acid and cholesterol biosynthesis. This beta1 subunit may positively regulate AMPK activity, and its myristoylation and phosphorylation can affect enzyme activity and cellular localization. It may also function as an adaptor molecule mediating AMPK complex association.
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