ELK Biotechnology PGI2 synthase rabbit pAb
PGI2 synthase를 인식하는 토끼 다클론 항체로, WB·ELISA·IHC에 사용 가능. 인간, 마우스, 랫트 반응성. ER 막에 위치하며 prostaglandin I2 합성 관련 연구에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C 보관.
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PGI2 synthase rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PGI2 synthase rabbit pAb |
| Alternative Names | PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 2000–20000 |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PGI2 synthase |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 57 kD |
| GeneID (Human) | 5740 |
| Human Swiss-Prot No | Q16647 |
| Cellular localization | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
However, this protein is considered a member of the cytochrome P450 superfamily based on sequence similarity rather than functional similarity.
This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation.
An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contributes to the development of myocardial infarction, stroke, and atherosclerosis.
[provided by RefSeq, Jul 2008]
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