ELK Biotechnology Plk1 (phospho Ser137) rabbit pAb
Plk1 (phospho Ser137) rabbit pAb는 인간 PLK1의 Ser137 인산화 부위를 인식하는 폴리클로날 항체로, WB, IF, ELISA, IHC에 적합합니다. 세포 분열 관련 단백질 연구 및 암세포 증식 억제 연구에 활용됩니다. 고순도 IgG, -20°C에서 1년 안정 저장.
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제품명
Plk1 (phospho Ser137) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
본 항체는 인간 PLK1 단백질의 Ser137 인산화 부위를 인식하도록 제작된 rabbit polyclonal 항체입니다. 세포 분열 및 암 연구에 적합하며, 다양한 응용 분야에서 높은 특이성과 재현성을 제공합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | PLK1; PLK; Serine/threonine-protein kinase PLK1; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13 |
| Applications | WB; IF; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IF/ICC 1:50–200; ELISA 1:2000–20000; IHC-p 1:50–200 |
| Immunogen | Synthesized peptide derived from human PLK1 around phosphorylation site of Ser137 (AA range: 103–152) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 68 kD |
| GeneID (Human) | 5347 |
| Human Swiss-Prot No | P53350 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Nucleus, chromosome (centromere, kinetochore), cytoplasm (cytoskeleton, microtubule organizing center, centrosome), spindle, midbody.
Localization at the centrosome starts at the G1/S transition (PubMed:24018379).
During early mitosis, the phosphorylated form is detected on centrosomes and kinetochores.
Localizes to the outer kinetochore and central spindle via phosphorylation and docking at midzone proteins KIF20A/MKLP2 and PRC1.
Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase.
배경 (Background)
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many types of cancer.
Depletion of this protein in cancer cells inhibits proliferation and induces apoptosis, making it a potential target for cancer therapy.
[provided by RefSeq, Sep 2015]
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