ELK Biotechnology Arrestin-β-1 rabbit pAb
Arrestin-β-1 rabbit polyclonal antibody for WB, IHC, IF, ELISA. Recognizes human ARRB1 peptide (AA 369–418). Detects 50 kD band. Suitable for human, mouse, and rat samples. Stored at −20 °C, 1 mg/ml concentration.
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Arrestin-β-1 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product Name | Arrestin-β-1 rabbit pAb |
| Alternative Names | ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 408 |
| Human Swiss-Prot No | P49407 |
| Species Reactivity | Human; Mouse; Rat |
실험 적용
| Application | Recommended Dilution |
|---|---|
| Western Blot (WB) | 1/500 – 1/2000 |
| Immunohistochemistry (IHC) | 1/100 – 1/300 |
| Immunofluorescence (IF) | 1/200 – 1/1000 |
| ELISA | 1/10000 |
| 기타 | Not yet tested in other applications |
Immunogen
The antiserum was produced against synthesized peptide derived from human ARRB1.
AA range: 369–418
저장 및 안정성
| 항목 | 내용 |
|---|---|
| Host | Rabbit |
| Storage Condition | −20 °C / 1 year |
세포 내 위치 (Cellular Localization)
Cytoplasm, nucleus, cell membrane, clathrin-coated pit, pseudopodium, cytoplasmic vesicle.
Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
Monomeric form predominantly located in the nucleus; oligomeric form in the cytoplasm.
Translocates to the nucleus upon stimulation of OPRD1 (By similarity).
Background
Members of the arrestin/beta-arrestin protein family participate in agonist-mediated desensitization of G-protein-coupled receptors, dampening cellular responses to hormones, neurotransmitters, or sensory signals.
Arrestin beta 1 acts as a cofactor in beta-adrenergic receptor kinase (BARK)-mediated desensitization of beta-adrenergic receptors.
It is highly expressed in peripheral blood leukocytes and plays a major role in regulating receptor-mediated immune functions.
Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
[provided by RefSeq, Jan 2011]
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