ELK Biotechnology PLC γ2 rabbit pAb
PLCγ2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 PLCG2 유래 펩타이드로 면역화됨. 세포 내 신호 전달 연구에 적합하며, -20°C에서 1년 보관 가능.
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PLC γ2 rabbit pAb
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| 항목 | 내용 |
|---|---|
| Alternative Names | PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PLCG2 (AA range: 1186–1235) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 147 kDa |
| Gene ID (Human) | 5336 |
| Human Swiss-Prot No. | P16885 |
| Cellular Localization | Intracellular, cytosol, plasma membrane, extracellular exosome |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. (Provided by RefSeq, Mar 2014)
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