Thermo Fisher Scientific Phospho-p53 (Ser9) Recombinant Rabbit Monoclonal Antibody (ARC1529)
Phospho-p53 (Ser9) 특이성을 가진 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현되었으며, 고순도 Affinity Chromatography로 정제된 액상 항체입니다. p53 신호전달 및 세포 스트레스 연구에 활용됩니다.
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- pk
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Thermo Fisher Scientific Phospho-p53 (Ser9) Recombinant Rabbit Monoclonal Antibody (ARC1529)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1529 |
| Immunogen | A synthetic phosphorylated peptide around S9 of human p53 (P04637) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849743 |
Product Specific Information
Immunogen sequence: DPSVE
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon stress, p53 activates transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is critical for p53 activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 plays a key role in blocking proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive functions such as long-term potentiation (LTP). Mutations in TP53 result in loss of tumor suppressor activity and are implicated in many cancers, including hereditary syndromes like Li-Fraumeni.
Usage
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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