Thermo Fisher Scientific B7-H4 (Immuno-Inhibitory Protein) Recombinant Rabbit Monoclonal Antibody (B7H4, 2652R)
Thermo Fisher Scientific의 B7-H4 (Immuno-Inhibitory Protein) 재조합 토끼 단클론 항체로, IHC, ICC/IF, Flow Cytometry에 적합합니다. 인간 시료 반응성이 있으며, Protein A/G로 정제된 액상 항체입니다. 면역억제 단백질 B7-H4의 연구용으로 사용됩니다.
- 카탈로그번호
- 79679-RBM2-P1
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific B7-H4 (Immuno-Inhibitory Protein) Recombinant Rabbit Monoclonal Antibody (B7H4, 2652R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B7H4, 2652R |
| Immunogen | A recombinant fragment of human B7-H4 protein (amino acids 32–147). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: Heat sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
B7-H4 (also known as B7x, VTCN1) is a costimulatory protein functioning as a negative regulator of T-cell mediated immunity. Although its receptor is unknown, B7-H4 delivers inhibitory signals to T-cells, suppressing proliferation, cell cycle progression, and interleukin-2 production.
It is expressed on activated T-cells, B-cells, monocytes, and dendritic cells. Aberrant expression has been linked to cancers of the lung, breast, and ovary. Overexpression may enable tumor cells to evade immune surveillance. VTCN1 is also considered a potential biomarker for early detection of ovarian cancer and renal cell carcinoma (RCC).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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